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human pbk model  (Simcyp)
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Simcyp human pbk model
Overview of identified major uncertainties related to metabolism and excretion processes of the available <t> PBK model </t> for acetamiprid.
Human Pbk Model, supplied by Simcyp, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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human pbk model - by Bioz Stars, 2026-08
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Overview of identified major uncertainties related to metabolism and excretion processes of the available PBK model for acetamiprid.

Journal: EFSA Journal

Article Title: Statement on the toxicological properties and maximum residue levels of acetamiprid and its metabolites

doi: 10.2903/j.efsa.2024.8759

Figure Lengend Snippet: Overview of identified major uncertainties related to metabolism and excretion processes of the available PBK model for acetamiprid.

Article Snippet: Although the Simcyp human PBK model was considered to be relevant, it could not be applied by the WG to answer assessment question 1b, since Simcyp Simulator software is a proprietary software that can only be used following a dedicated training.

Techniques: Radioactivity, Selection, In Vivo

Schematic overview of interrelation of identified uncertainties related to metabolism and excretion processes of acetamiprid and IM‐2‐1 in the available PBK model for acetamiprid. The PBK model parameter values chosen for the kinetic processes related to U1, U2 and U4 impact on predicted internal and urinary acetamiprid concentrations (U6). The PBK model parameter values chosen for the kinetic processes related to U1–U5 impact on predicted internal and urinary IM‐2‐1 concentrations (U7).

Journal: EFSA Journal

Article Title: Statement on the toxicological properties and maximum residue levels of acetamiprid and its metabolites

doi: 10.2903/j.efsa.2024.8759

Figure Lengend Snippet: Schematic overview of interrelation of identified uncertainties related to metabolism and excretion processes of acetamiprid and IM‐2‐1 in the available PBK model for acetamiprid. The PBK model parameter values chosen for the kinetic processes related to U1, U2 and U4 impact on predicted internal and urinary acetamiprid concentrations (U6). The PBK model parameter values chosen for the kinetic processes related to U1–U5 impact on predicted internal and urinary IM‐2‐1 concentrations (U7).

Article Snippet: Although the Simcyp human PBK model was considered to be relevant, it could not be applied by the WG to answer assessment question 1b, since Simcyp Simulator software is a proprietary software that can only be used following a dedicated training.

Techniques: